Regenerative medicine is an ever-emerging field of medical science, focused on using stem cells and biological growth factors to heal and regenerate injured tissue such as ligaments, tendons, joints, and cartilage. This can be done through the use of stem cell injections, platelet-rich plasma (PRP), prolotherapy, and more.
While regenerative medicine is able to show great promise in helping to treat many different diseases and conditions, sometimes these treatments are recommended to be supported by specific supplements. This is where TRF and SPM supplement support come into play.
Tissue Regenerative Factor (TRF) is a bone-derived supplement consisting of protein and collagen that is designed to provide nutritional support for healthy bones and joint function. Specialized Pro-Resolving Mediator (SPM) is a fish oil-derived supplement intended to support and resolve your body’s immune response. To put it simply, SPM helps to prevent excessive inflammation and remove damaged cells and tissue from the body, while TRF promotes and helps expedite the regeneration of new healthy tissue.
A protein-dense supplement, such as (TRF), can give your body the support it needs to promote optimal healing while receiving regenerative treatments. This powerful supplement has been shown to help with bone and tissue rebuilding, making it the perfect complement to the treatments and therapies provided at Greenberg Regenerative Medicine.
The purpose of combining this supplement with treatment is to optimize the immune system as much as possible during the tissue-rebuilding process. Dr.Greenberg typically recommends his patients take TRF supplements 1-2 times per day while receiving treatment as he says this will enhance and “promote the regenerative effect of healing.” The goal of this combination is to maximize benefit and speed up the tissue-healing process.
Gel capsules, glass supplement bottleSupplements work with the body, basically augmenting the body’s natural effects, while medications work to alter the body’s biological and chemical mechanisms. Using supplements to aid in the healing process is meant to be a long term action. Medications such as aspirin, for example, are taken for more of an instantaneous effect (i.e. relieving a headache).
TRF supplements are often paired with other recommended supplements as a form of regimen. SPM is always paired with TRF under Dr. Greenberg’s recommendations. The complementary supplement, as mentioned earlier, is derived from fish oil and helps to reduce inflammation in the body. These two supplements go hand in hand because one, TRF, promotes the healing and regenerative process of tissue-building, while the other, SPM, aids in the removal of debris and damaged tissues to make way for the new. “It’s a piece of the puzzle,” says Dr. Greenberg. “Everything is a little bit unique in regards to why we use something and what we’re using it for.” When patients use TRF and SPM supplements as a regimen while receiving their treatments, patients will receive the optimum benefits within the shortest period of time.
If you are interested in receiving regenerative treatments and supplement support for conditions such as arthritis, cervicocranial syndrome, pelvic tilt, and more, call the GRM office today about whether this approach might be right for you. With the right combination of regenerative therapies and supplement support, you can achieve optimal health and healing for many years to come.
Looking to treat your chronic pain safely while improving the quality of your life? Schedule a consultation with Greenberg Regenerative Medicine’s team to determine a plan that is best suited for your needs.
For many years, it was assumed that inflammation is a self-limiting process, but discoveries showed the presence of an active process, that is promoted by a group of molecules called specialized-pro resolving mediators (SPM).
Let’s imagine this nice analog.
There is a pipe leaking inside your home wall.. this will damage the surrounding structures and it must be fixed early, isn’t it?
This pipe likes an injury or infection in your body, that affects the surrounding tissues and triggers the inflammation process.
You will call workers for help, to make a hall in the wall to get access to the pipe. once the damage from the leak has been contained, you will start to cut out affected structures.
This is actually what happens in case of injury, the injury sends signals to the immune system and calls the immune cells (neutrophils) to contain the damage. then the immune cells will kill the infected cells beyond repair.
Now, this mess needs to be cleared for workers to repair the pipe, then the finishing touches restore the wall as if nothing ever happened.
Here is the role of SPMs respectively
Specialized pro-resolving mediators are lipid mediators present in our body derived from poly-unsaturated fatty acids,
It demonstrated to have an important role in inflammation by preventing overaction of the causative organism, promoting the resolution of inflammation.
SPMs are derived from poly-unsaturated fatty acids like AA(Arachidonic acid), EPA(Eicosapentaenoic acid(, and DHA(docosahexaenoic acid).
It has a potential therapeutic role in the body. Because chronic or uncontrolled inflammation plays a key role in a variety of diseases like; cardiovascular diseases and metabolic syndrome.
Chronic pain is one of the most frequent and difficult-to-manage clinical issues in medical practice, it is highly related to disorders leading to disability.
Chronic pain affects the quality of life-related to physical activities and restrictions of mobility, as well as anxiety and depression.
Uncontrolled inflammation, especially neuroinflammation, is the main pathophysiologic component of chronic pain.
Recent studies have shown anti-nociceptive effects for specialized pro-resolving mediators (SPMs).
They are important regulators of the balance between pro-inflammatory and anti-inflammatory substances. They also might regulate the excessive sensitization of nociceptors after inhibiting specialized channels, therefore achieving the suppression of pain.
There is a meta-analysis(the strongest type of clinical study) done by Goldberg et al included 17 trials that evaluate the pain-relieving effects of SPMs on patients with rheumatoid arthritis and related joint disorders of inflammatory diseases and dysmenorrhea.
The study showed that SPM supplementation reduced the patient-reported joint pain and intensity and morning stiffness.
SPMs may have the capacity for modulation of neuroinflammation like the pain results from the connection between immune and nervous cells. Chronic uncontrolled inflammation is associated with mental health disorders like depression, anxiety, bipolar disorders, and schizophrenia.
SPM production may be impaired with mental health problems like depression, and mood disorders are also associated with chronic inflammation, which is controlled by SPMs, so SPM Active can be beneficial for mental health problems such as depression and mood disorders.
Recent evidence showed that any alteration in SPMs function may cause proinflammatory and neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis(MS).⁴
Athletics and sports practitioners are always susceptible to injuries and inflammation, that may reduce their performance and recovery, so it is important to support them with a compound that resolves the inflammation without compromising the immune response. This is the role of SPM Active.
Yes, SPMs may help in sports performance. it supports natural recovery from injuries and inflammation and helps to sustain performance.
It also promotes the reduction of pain and tissue regeneration.
A study showed that fish oil supplements (DHA&EPA), the main active ingredient of SPM active, can help in muscle recovery, cognition, and cardiovascular dynamics in cyclists. It also helps in pro-inflammatory cell responses and increases lipid peroxidation and post-exercise nitric oxide.
To choose the best SPM supplement you should take care of some points like, the producing company must follow the quality requirements, and the formula must have undergone clinical studies to discover the potential benefits from it. you should also read the label of the supplement to ensure it is according to your needs.
Other information included in the supplement label like pill size and storage conditions.
You can check the supplement label of our ultimate SPM supplement, SPM Active., Which is clinically studied, And The online access to quality test information for every batch assures the quality of the product,(see the product info).
In conclusion, the inflammation process must be controlled by SPMs molecules, Hence the role of SPM is active in the healing process and neuroinflammation and mental health, athletics, and sports performance.
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Can SPM Active be used to improve mental health? This article examines the potential benefits of SPM Active for mental health and explores the evidence behind it.
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